Psoriasis is a kind of refractory disease, though it is less serious than cancer. The etiology is not clear, the morbidity is high, and it cannot be radically cured. It is an urgent problem that needs to be solved. Since 1980, the authors have studied the pathogenic mechanisms of psoriasis from aspects of pathology, biochemistry, pharmacology, and immunology. It was proved that abnormalities in biochemical components, neural media, immunological state and cell metabolism existed in psoriatic cases. We have published more than ten articles, and formulated two anti-psoriasis drugs, which is reported as follows:　　1. The levels of serum zinc, copper, calcium, magnesium, iron, selenium, ceruloplasmin, vitamin A and vitamin E in 138 psoriatic patients were measured by atomic absorption spectrometry. The results showed that serum copper level in the progressive and stable stage was decreased significantly (P<0.01). The levels of serum calcium and vitamin E lowered too. The levels of serum ceruloplasmin,　selenium and iron were considerably higher in psoriatic than those in the normal control. This is an evidence that there are biochemical abnormalities in the internal environment of psoriatic patients.

据GB/T 15481-2000idtISO/IEC 17025:1999规定[1],校准实验室或进行自校准的检测实验室,对所有的校准和各种校准类型都应具有并应用评定测量不确定度的程序.构成不确定度的来源,包括(不限于)所用的参考标准和标准物质、方法和设备、环境条件、被检测或校准物质的性能和状态以及操作人员.