Psoriasis is a kind of refractory disease, though it is less serious than cancer. The etiology is not clear, the morbidity is high, and it cannot be radically cured. It is an urgent problem that needs to be solved. Since 1980, the authors have studied the pathogenic mechanisms of psoriasis from aspects of pathology, biochemistry, pharmacology, and immunology. It was proved that abnormalities in biochemical components, neural media, immunological state and cell metabolism existed in psoriatic cases. We have published more than ten articles, and formulated two anti-psoriasis drugs, which is reported as follows:　　1. The levels of serum zinc, copper, calcium, magnesium, iron, selenium, ceruloplasmin, vitamin A and vitamin E in 138 psoriatic patients were measured by atomic absorption spectrometry. The results showed that serum copper level in the progressive and stable stage was decreased significantly (P<0.01). The levels of serum calcium and vitamin E lowered too. The levels of serum ceruloplasmin,　selenium and iron were considerably higher in psoriatic than those in the normal control. This is an evidence that there are biochemical abnormalities in the internal environment of psoriatic patients.

我们对17例小儿腹膜后恶性肿瘤患儿的血清、头发及肿瘤组织中锌、铜、铁含量进行了测定.结果表明肿瘤组发铜明显高于血铜,血锌明显低于对照组、瘤组织及头发.肿瘤组血清铜/锌比值明显高于对照组,与文献报告一致.