目前,常用的制作人体骨骼标本的方法有水煮法[1,2 ]、药液浸泡法[3,4]、自然腐蚀法[5]等,处理过程较为复杂,且有碍环境卫生.为了给教学、医疗提供优质的骨骼标本,我们利用收集到的腐烂尸体,在自然腐蚀法的基础上经过改进,将尸体砌池掩埋,制作数套完整的人体骨架标本.现将制作方法介绍如下.

Fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) signaling plays essential roles in bone development and diseases. Missense mutations in FGFs and FGFRs in humans can cause various congenital bone diseases, including chondrodysplasia syndromes, craniosynostosis syndromes and syndromes with dysregulated phosphate metabolism. FGF/FGFR signaling is also an important pathway involved in the maintenance of adult bone homeostasis. Multiple kinds of mouse models, mimicking human skeleton diseases caused by missense mutations in FGFs and FGFRs, have been established by knock-in/out and transgenic technologies. These genetically modified mice provide good models for studying the role of FGF/FGFR signaling in skeleton development and homeostasis. In this review, we summarize the mouse models of FGF signaling-related skeleton diseases and recent progresses regarding the molecular mechanisms, underlying the role of FGFs/FGFRs in the regulation of bone development and homeostasis. This review also provides a perspective view on future works to explore the roles of FGF signaling in skeletal development and homeostasis.