外科手术切口感染是最常见的医院感染,据统计,在我国发生率为8.4%[1],在医院感染中居第三位[2],外科切口感染给临床带来的危害愈来愈受到医务人员的重视.为了降低手术切口的感染率,本文就切口感染的因素加以分析并提出防范对策.现总结如下.

Objective To explore the effect and mechanism of early using specific immune RNA (iRNA) for preventing burn infection.Method 129 patients with serious burn were randomly divided into two groups by double blind method. The control group (n=64) was treated with routine method; The therapeutic group(n= 65) was given specific iRNA in addition to the routine therapy. The incidence of infection in two groups were investigated; Meantime, with the methods of monoclonal antibody (McAb) APAAP, 3H- TdR incorporation and MTT colorimetery, the various immune functions of patients were determined. Result (1) the incidences of wound infection and bacteriemia after burn in the therapeutic group were markedly lower than those of the control group; (2) the therapeutic group was also superior to the control group in the general condition and time of the wound healing; (3) on the l0th day postburn, the various immune founction tested in the therapeutio group have approximately restored to the normal levels, while those in the control group were still in low levels. The difference between the two groups was statistically significant (P＜0.01). Conclusion Specific iRNA, which, when used early after burn, can reduce the incidence of postburn infection, and improve immune functions of burned patients.

我院自1983年12月开始对小儿急性阑尾炎术前加用灭滴灵直肠栓剂预防切口感染,现将其疗效报道如下:临床资料以1983年12月～1984年12月我院收治的小儿急性阑尾炎切除术66例为灭滴灵组,所有患儿术前0.5～1小时常规应用灭滴灵直肠栓剂0.5～1.0g,其中剔除经原切口烟卷引流和二期缝合切口者4例,余62例.