Hepatocarcinoma is a disease that threatens human health. To date,the known etiology of hepatocarcinomahas not been narrowed down to just one factor. It is possible that there are their own causes in different areas.Thus, there are no absolute, but relative therapy to cure all kinds of hepatocarcinoma. Presently,there exists other treatment for the hepatocarcinoma which cannot be operated by surgery, such as cryosurgery,photodynamic therapy,immunotherapy,interventional radiotherapy and targeting therapy.With the development of molecular biology ,gene therapy offers new possibilities in the treatment of genetic diseases,tumors,AIDS and other gene defect disease.

1 Genetic disease Genetic disease is one of the top classes of human diseases.Several thousand types of human genetic diseases have been identified.Most of the family may contain genetic disorders,and at least 10 percent of all adults contain genetic defects (http://www.britannica.com/EBchecked/topic/228874/human-geneticdisease) [1].In China,over 1 million new born babies have genetic birth deficiency annually (http://www.dcmst.org.cn/bencandy.php? fid =14&id =273 ).While the individuals with genetic diseases passed away before reaching the reproduction age will eliminate the diseases from the human population,the individuals reaching the reproduction age will transmit the diseases to the new generation,therefore,the diseases will remain in the human population.China has the largest human population in the world and Shandong is one of the most populated provinces in China.In the foreseeable future,most of the genetic diseases will not be curable.