Expert Opinion on Drug Metabolism & Toxicology

Advanced drug discovery technologies are yielding a dramatic increase in the number of potential drug candidates. However, optimisation of these compounds is becoming increasingly reliant on absorption, distribution, metabolism and excretion (ADME), and toxicological (Tox) issues, a major bottleneck in the drug discovery process. At least 50% of all drug failures in pharmaceutical research are believed to be due to ADME-Tox considerations. Therefore, the ability to solve the ADME-Tox issues of a drug candidate before clinical testing has become of utmost importance in rendering the drug development process more efficient and cost-effective. Furthermore, the continued study of metabolic, pharmacokinetic and toxicological issues surrounding existing compounds is of great importance in the optimisation of drug regimens and therapeutic strategies. Through systematic review and evaluation, Expert Opinion on Drug Metabolism & Toxicology provides a forum for the commentary and analysis of current and emerging research approaches in the ADME-Tox arena, as well as metabolic, pharmacokinetic and toxicological issues relating to specific drugs or drug classes. The journal contains the following article types: Reviews - cover every aspect of drug metabolism and toxicology including in vitro assays, toxicology screens, in vitro, in vivo and in silico ADME models, and pharmacokinetic studies; Drug Evaluations - assess metabolic, pharmacokinetic and toxicological issues related to a specific drug; Technology Profiles - provide analysis of individual technologies, offering readers a comprehensive overview of the specific technology under review; Perspectives - highlight areas of controversy and debate within the field; Meeting Highlights - provide coverage of recent related conferences; Editorials - cover important issues pertaining to drug metabolism and toxicology. The audience consists of scientists and managers in the healthcare and pharmaceutical industry, academic pharmaceutical scientists and related professionals.