Objective: To evaluate the therapeutic effect of Yangxin Fumai Oral Liquid (YFOL,养心复脉口服液), a Chinese herbal medicine for nourishing Heart and restoring pulse, in treating patients with extrasystole. Methods: The effect of YFOL was observed in treating 30 patients with different kinds of extrasystole and compared with that in 30 patients treated by propafenone. The effect of YFOL on experimental arrhythmia was studied in animals as well. Results: Clinical observation showed that the effect of treatment against extrasystole in the two groups was similar, but the YFOL group showed better results in symptom improvement (P<0.01) with no marked side-effect. Experimental study showed that YFOL could reduce the chloroform induced ventricular fibrillation occurrence in mice, delay the initiating time of ventricular extrasystole, tachycardia and fibrillation induced by aconitine, BaCl2 and coronary artery ligation in rats, or shorten the lasting time of arrhythmia, reduce the attacking frequency of ventricular extrasystole. There was significant difference in comparing with the control group (P<0.05, P<0.01). Conclusion:YFOL is a good and convenient Chinese herbal preparation for different kinds of extrasystole with few toxic and side-effect in clinical practice.

早搏是一种常见的心律失常,可见于多种心血管系统疾患,患者轻者活动受限,重者可危及生命.我们在治疗早搏的有效中药制剂"养心复脉口服液"研究基础上[1]通过正交试验并结合多年临床经验,对原处方又加以筛选优化制成无糖型颗粒剂--脉安颗粒.

目的:观察养心复脉口服液抗实验性心律失常的作用.方法:采用鸟头碱、氯化钡和冠状动脉结扎致大鼠心律失常的方法,探讨养心复脉口服液的抗心律失常的作用.结果:养心复脉口服液(19g·kg-1·d-1×7d,38g·kg-1·d-1×7d,ig)可明显对抗鸟头碱、氯化钡、冠状动脉结扎诱发的大鼠心律失常,其特点是提高鸟头碱致大鼠室性早搏(VPB)、室性心动过速(VT)和心室颤动(VF)的剂量,推迟氯化钡致大鼠VPB和VT的发生时间及缩短大鼠心律失常的持续时间,降低冠状动脉结扎所致大鼠VPB的发生率.结论:养心复脉口服液具有较好的抗心律失常作用.