MOLECULAR BIOLOGY OF THE CELL

Molecular Biology of the Cell (MBoC) is an online journal published twice monthly and owned by the American Society for Cell Biology (ASCB). Unredacted accepted manuscripts are freely accessible immediately through MBoC In Press. Final published versions are freely accessible two months after publication at www.molbiolcell.org. MBoC is also available online through PubMed Central, sponsored by the U.S. National Library of Medicine. Access earlier than two months is available through subscription or membership in the ASCB. Scope of MBoC MBoC publishes research articles and essays that report the results of original research and present conceptual advances of broad interest and significance within all areas of cell biology, genetics, and developmental biology. Manuscript submissions whose scope bridges several areas of cell and developmental biology are particularly encouraged. MBoC publishes articles that describe substantial research progress in full. Therefore, authors should include with their manuscript submissions all previously unpublished data and methods essential to support the conclusions drawn. MBoC does not, in general, publish articles that are narrow in scope and better suited to more specialized journals, merely confirmatory or preliminary reports of partially completed or incompletely documented research, findings of as yet uncertain significance, or reports that simply document well-known processes in organisms or cell types not previously studied. Submissions that report new methodologies will be considered only when a new result of biological significance has been achieved or when introduction of the method will significantly accelerate progress within a field. Note that MBoC places a premium on research articles that present conceptual advances of wide interest or deep mechanistic understanding of important CELLULAR processes. As such, articles dealing principally with describing behavior or modification of specific transcription factors, or analysis of the promoter elements through which they interact, will not generally be considered unless accompanied by information supporting in vivo relevance or broad significance.